Warfarin: Any harm in long-term use?

Warfarin (Coumadin) is a blood-thinning medication (anticoagulant) used to treat and prevent blood clots. For most people with a single episode of deep vein thrombosis (DVT), treatment with full-dose blood thinners is usually for only a limited time.

Long-term, low-dose treatment with warfarin may prevent future episodes of DVT, but the risk of bleeding may be a concern. In fact, in October 2006, warnings about the risk of serious or even fatal bleeding — especially when warfarin is taken in high doses or for long periods of time — were added to the medication's label.

Ask your doctor to help you weigh the benefits and risks of long-term warfarin therapy in your case. Also consider these self-care measures to prevent future episodes of DVT:

• Avoid sitting, squatting or crossing your legs for long periods of time.
• If you must sit for long periods, such as during a plane ride, take a short walk every hour. It also helps to curl your toes and tap your feet frequently.
• Drink plenty of fluids to prevent dehydration.
• Wear support hosiery or compression stockings, available at medical supply stores.